Abstract
It takes a fraction of a second to recognize a person or an object even when seen under strikingly different conditions. How such a robust, high-level representation is achieved by neurons in the human brain is still unclear. In monkeys, neurons in the upper stages of the ventral visual pathway respond to complex images such as faces and objects and show some degree of invariance to metric properties such as the stimulus size, position and viewing angle. We have previously shown that neurons in the human medial temporal lobe (MTL) fire selectively to images of faces, animals, objects or scenes. Here we report on a remarkable subset of MTL neurons that are selectively activated by strikingly different pictures of given individuals, landmarks or objects and in some cases even by letter strings with their names. These results suggest an invariant, sparse and explicit code, which might be important in the transformation of complex visual percepts into long-term and more abstract memories.
| Original language | English |
|---|---|
| Pages (from-to) | 1102-1107 |
| Number of pages | 6 |
| Journal | Nature |
| Volume | 435 |
| Issue number | 7045 |
| DOIs | |
| State | Published - 23 Jun 2005 |
Funding
| Funders | Funder number |
|---|---|
| Gordon Moore Foundation | |
| Swartz Foundation for Computational Neuroscience | |
| National Science Foundation | |
| Office of Naval Research | |
| National Institute of Mental Health | |
| National Institute of Neurological Disorders and Stroke | |
| Defense Advanced Research Projects Agency | |
| Alfred P. Sloan Foundation |
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Quiroga, R. Q., Reddy, L., Kreiman, G., Koch, C. (2005). Invariant visual representation by single neurons in the human brain. Nature, 435(7045), 1102-1107. https://doi.org/10.1038/nature03687
Quiroga, R. Quian ; Reddy, L. ; Kreiman, G. et al. / Invariant visual representation by single neurons in the human brain. In: Nature. 2005 ; Vol. 435, No. 7045. pp. 1102-1107.
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title = "Invariant visual representation by single neurons in the human brain",
abstract = "It takes a fraction of a second to recognize a person or an object even when seen under strikingly different conditions. How such a robust, high-level representation is achieved by neurons in the human brain is still unclear. In monkeys, neurons in the upper stages of the ventral visual pathway respond to complex images such as faces and objects and show some degree of invariance to metric properties such as the stimulus size, position and viewing angle. We have previously shown that neurons in the human medial temporal lobe (MTL) fire selectively to images of faces, animals, objects or scenes. Here we report on a remarkable subset of MTL neurons that are selectively activated by strikingly different pictures of given individuals, landmarks or objects and in some cases even by letter strings with their names. These results suggest an invariant, sparse and explicit code, which might be important in the transformation of complex visual percepts into long-term and more abstract memories.",
author = "Quiroga, {R. Quian} and L. Reddy and G. Kreiman and C. Koch and I. Fried",
note = "Funding Information: Acknowledgements We thank all patients for their participation; P. Sinha for drawing some faces; colleagues for providing pictures; I. Wainwright for administrative assistance; and E. Behnke, T. Fields, E. Ho, E. Isham, A. Kraskov, P. Steinmetz, I. Viskontas and C. Wilson for technical assistance. This work was supported by grants from the NINDS, NIMH, NSF, DARPA, the Office of Naval Research, the W.M. Keck Foundation Fund for Discovery in Basic Medical Research, a Whiteman fellowship (to G.K.), the Gordon Moore Foundation, the Sloan Foundation, and the Swartz Foundation for Computational Neuroscience.",
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Quiroga, RQ, Reddy, L, Kreiman, G, Koch, C 2005, 'Invariant visual representation by single neurons in the human brain', Nature, vol. 435, no. 7045, pp. 1102-1107. https://doi.org/10.1038/nature03687
Invariant visual representation by single neurons in the human brain. / Quiroga, R. Quian; Reddy, L.; Kreiman, G. et al.
In: Nature, Vol. 435, No. 7045, 23.06.2005, p. 1102-1107.
Research output: Contribution to journal › Article › peer-review
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AU - Kreiman, G.
AU - Koch, C.
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N1 - Funding Information:Acknowledgements We thank all patients for their participation; P. Sinha for drawing some faces; colleagues for providing pictures; I. Wainwright for administrative assistance; and E. Behnke, T. Fields, E. Ho, E. Isham, A. Kraskov, P. Steinmetz, I. Viskontas and C. Wilson for technical assistance. This work was supported by grants from the NINDS, NIMH, NSF, DARPA, the Office of Naval Research, the W.M. Keck Foundation Fund for Discovery in Basic Medical Research, a Whiteman fellowship (to G.K.), the Gordon Moore Foundation, the Sloan Foundation, and the Swartz Foundation for Computational Neuroscience.
PY - 2005/6/23
Y1 - 2005/6/23
N2 - It takes a fraction of a second to recognize a person or an object even when seen under strikingly different conditions. How such a robust, high-level representation is achieved by neurons in the human brain is still unclear. In monkeys, neurons in the upper stages of the ventral visual pathway respond to complex images such as faces and objects and show some degree of invariance to metric properties such as the stimulus size, position and viewing angle. We have previously shown that neurons in the human medial temporal lobe (MTL) fire selectively to images of faces, animals, objects or scenes. Here we report on a remarkable subset of MTL neurons that are selectively activated by strikingly different pictures of given individuals, landmarks or objects and in some cases even by letter strings with their names. These results suggest an invariant, sparse and explicit code, which might be important in the transformation of complex visual percepts into long-term and more abstract memories.
AB - It takes a fraction of a second to recognize a person or an object even when seen under strikingly different conditions. How such a robust, high-level representation is achieved by neurons in the human brain is still unclear. In monkeys, neurons in the upper stages of the ventral visual pathway respond to complex images such as faces and objects and show some degree of invariance to metric properties such as the stimulus size, position and viewing angle. We have previously shown that neurons in the human medial temporal lobe (MTL) fire selectively to images of faces, animals, objects or scenes. Here we report on a remarkable subset of MTL neurons that are selectively activated by strikingly different pictures of given individuals, landmarks or objects and in some cases even by letter strings with their names. These results suggest an invariant, sparse and explicit code, which might be important in the transformation of complex visual percepts into long-term and more abstract memories.
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Quiroga RQ, Reddy L, Kreiman G, Koch C, Fried I. Invariant visual representation by single neurons in the human brain. Nature. 2005 Jun 23;435(7045):1102-1107. doi: 10.1038/nature03687
